This study was carried out to investigate the effect of water extracts from 4-, 5- and 6-year old red white ginseng roots on the inhibition of lipolysis in fat cell induced by toxohormone-L which has been known as lipolytic and anorexigenic
factors.
Toxohormone-L was obtained by partial purification of the ascites fluid from mice which had been inoculated with sarcoma-180. Each water extract of ginseng was effective in vitro against the inhibition of lipolysis induced by the toxohormone-L at
the
concentrations over 10~100μg/ml. At the concentration of 1,000μg/ml, the inhibition ratio of lipolysis by the water extracts of 4-, 5- and 6-year old white ginseng roots were 56.3, 59.7 and 59.4%, and those of red ginseng was the most effective
in the
inhibition of the lipolysis. The total inhibition activity activity per gram of ginseng sample was higher in the 4-year and 5-year old white ginseng roots at the concentrations of 100μg/ml and 1,000ug/ml, respectively, while for the red ginseng
it
was
higher in the 6-year old ginseng than ages regardless of the reaction concentration. Only once injection of the ginseng extracts(300mg/ml in saline solution) with 10*/g of weight to the mice bearing sarcoma-180 was not effective against the
extension of
their life spans. On the contrary, the life spans of the mice were rather shortened by the injection of 5-year old white ginseng and 6-year old red ginseng, as compared to that control.
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